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Home»Health»Covid Drug Paxlovid Now Less Effective Than In Early Trials—But It’s Still Great At Preventing Death
Health

Covid Drug Paxlovid Now Less Effective Than In Early Trials—But It’s Still Great At Preventing Death

September 23, 2023No Comments3 Mins Read
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Covid Drug Paxlovid Now Less Effective Than In Early Trials—But It’s Still Great At Preventing Death
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Topline

Paxlovid—Pfizer’s antiviral Covid-19 treatment—is 37% effective at preventing hospitalization or death in high-risk patients compared with no treatment, according to a study published Thursday in the JAMA Network Open, well below the 88% effectiveness rate Pfizer and regulators reported in clinical trials in 2021—though it remains very effective at staving off death.

In this photo illustration, Pfizer’s Paxlovid is displayed on July 07, 2022 in Pembroke Pines, … [+] Florida. (Photo by Joe Raedle/Getty Images)

Getty Images

Key Facts

The study found that when excluding hospitalizations and looking at death alone, the drug is 84% effective.

The observational study analyzed electronic health records from thousands of patients at the Cleveland Clinic Health System in 2022 and early 2023 to determine Paxlovid’s effectiveness, using real-world data rather than the clinical trials that were used before.

The study also found another antiviral Covid-19 treatment, Merck’s Lagevrio, was 42% effective in preventing hospitalization or death and 77% effective against death alone.

What We Don’t Know

Why the effectiveness has fallen. The study authors noted the clinical trials were conducted among unvaccinated patients who had limited natural immunity, whereas this study was conducted in a real-world population including vaccinated and previously infected patients who had some other defenses against the coronavirus. They also noted the original clinical studies were completed when the Delta variant was the most common strain of the virus while their study was conducted when the Omicron variant was, suggesting that the drug could work differently with different strains.

News Peg

While they note the effectiveness has fallen, the study’s authors still say these drugs are useful tools in fighting Covid-19, arguing both drugs can be used in nonhospitalized Covid-19 patients to prevent the most severe outcomes.

Crucial Quote

Paxlovid is still “definitely recommended for high-risk patients,” said University of North Carolina professor Danyu Lin, one of the study’s authors, according to Bloomberg.

Key Background

Paxlovid, a course of oral pills, first became available in December 2021 and is to be taken early in a patient’s infection. They’re designed to prevent patients who already have Covid-19 from becoming hospitalized or dying, particularly patients who are at an elevated risk of severe Covid-19 due to age or medical conditions. New information on Paxlovid’s effectiveness comes amid fears of a new wave of Covid-19 this fall. In the week ending September 9, 20,538 people were hospitalized for Covid-19, a 7.7% increase over the week prior, according to the Centers for Disease Control and Prevention. Since the onset of the pandemic, 1.14 million people have died of the virus.

Further Reading

Nirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections (JAMA Network Open)

Pfizer’s Paxlovid Covid Pill Granted Full FDA Approval (Forbes)

WHO Endorses Pfizer’s Antiviral Pill Paxlovid For High-Risk Covid Patients But Says Benefits ‘Trivial’ For Low-Risk Groups (Forbes)

Full coverage and live updates on the Coronavirus

See also  RIP Bob Barker died at 99, latest celebrity death of Price is Right host
Covid death Drug early Effective great Paxlovid preventing TrialsBut
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