Mayim Bialik reflected on her “nightmare” experience on a GLP-1 medication in a piece published in The Free Press on June 5.
According to the Big Bang Theory alum, three doctors suggested she try a GLP-1 due to its reported ability to curb the systemic inflammation linked to autoimmune conditions.
“I was exhausted from being sick, from the endless parade of specialists, from the diets, the protocols, and the promises. Maybe this could be the magic cure,” she wrote.
After taking one shot of the lowest dose of a synthetic GLP-1, she reportedly had an “explosive, uncontrollable diarrhea.”
Bialik detailed, “Sulfur burps so violent they left me afraid to open my mouth in public. Sneezing attacks every time I tried to eat or drink — which apparently has a name, snatiation. Cramping. Bloating. Full-body aching, as though I had the flu. And an inability to keep down even small sips of water without sprinting to the bathroom with yet more explosive diarrhea. More than three times, I didn’t make it.”
She also reportedly experienced what she described as something “closer to an allergic reaction.” Her symptoms became so severe that a nurse was called to her home to administer IV fluids.
“Extreme side effects, they told me, were not unusual. I couldn’t wrap my head around that – and seeing a gastroenterologist at this stage was deemed overly conservative. How could a reaction even half as severe as mine be considered normal?” she asked.

